Influence of dental implant surfaces on oral biofilms and host immune response.

ABSTRACT:

Background

Peri-implantitis, driven by microbial‒host immune interactions, is the leading reason that dental implants fail. Implant surface design plays a crucial role in microbial colonization.

Objective

To investigate how surface characteristics of implant materials impact periodontal disease biofilm formation and host immune response.

Design

Biofilms, cultured on Ti-6Al-4V and CoCr disks, had biomass quantified by crystal violet and microbial populations by agar enumeration. We assessed the influence of Ti-6Al-4V post-processing treatments on surface chemistry (energy dispersive spectroscopy), topography (optical profilometry) and microbial dynamics (through complex oral biofilm culture and 16S rRNA sequencing). To evaluate immune responses, biofilms were co-cultur

SUBMITTER: Vernon JJ 

PROVIDER: S-EPMC12777868 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature