Management of potentially curable colorectal lung metastases with synchronous systemic therapy and percutaneous image-guided thermal ablation.

ABSTRACT:

Objective

To assess the survival benefit of synchronous systemic therapy plus thermal ablation (TA) in oligometastatic colorectal lung metastases (CRLM) and identify independent prognostic factors.

Background

Optimizing the integration of systemic therapy and TA for potentially curable CRLM remains a significant clinical challenge.

Methods

This study employed a retrospective cohort design, including 326 patients who underwent TA treatment at six tertiary medical centers from March 2014 to October 2022. Patients were categorized into synchronous therapy, upfront ablation, delayed ablation, and no systemic therapy groups based on the timing of systemic therapy relative to TA. Kaplan-Meier analysis and log-rank tests were used to assess survival outcomes.

Results

SUBMITTER: Fan H 

PROVIDER: S-EPMC12777934 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature