Viral, Clinical, and Epidemiological Characteristics of Oropouche Fever in Southeastern Brazil.

ABSTRACT:

Background

Oropouche virus (OROV), an arbovirus causing acute febrile illness, was mostly restricted to the Amazon basin until 2023, when a reassortant lineage spread across Latin America. Increasing numbers of cases have subsequently been reported in extra-Amazonian regions of Brazil. However, follow-up and detailed clinical description is limited. This study aimed to describe viral, clinical, and epidemiological characteristics of OROV cases in the Brazilian states of Rio de Janeiro and Minas Gerais.

Methods

This longitudinal study enrolled adults with OROV exposure. Clinical and laboratorial data were assessed, and serum, urine, and saliva samples were tested for OROV RNA and sequenced.

Results

From December 2024 to May 2025, 55 OROV cases were recruited (median ag

SUBMITTER: Martins EB 

PROVIDER: S-EPMC12777973 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature