Effects of phenylephrine and norepinephrine with restrictive infusion on oxygenation during one-lung ventilation for lung surgery: a randomized controlled trial.

ABSTRACT:

Objective

This study compared the effects of norepinephrine or phenylephrine combined with restrictive infusion on the oxygenation during thoracoscopic one-lung ventilation (OLV).

Methods

Ninety patients were randomly divided into three groups: the norepinephrine group (Group N), the phenylephrine group (Group P), and the control group (Group C). Arterial partial pressure of oxygen (PaO₂) and intrapulmonary shunt fraction (Qs/Qt) were measured with patients in lateral positions during two-lung ventilation (TLV) at 10 min (T1), and during OLV at 15 min (T2) and 45 min (T3). Lung tissue samples were analyzed for endothelin and COX-2 levels after surgery.

Results

At T3, Group P had significantly higher PaO₂ and lower Qs/Qt than Groups N and C (all <

SUBMITTER: Li J 

PROVIDER: S-EPMC12777999 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature