Clinical impact of disease stability on exacerbation and mortality in COPD: a retrospective cohort study.

ABSTRACT:

Background

Disease stability is an achievable goal in chronic obstructive pulmonary disease (COPD) management. However, the clinical implications of disease stability in patients with COPD remain unclear.

Methods

We conducted a single-center retrospective cohort study using the electronic medical records of treated patients with symptomatic COPD. Patients who had newly initiated inhaler therapy with long-acting β2-agonist/long-acting muscarinic antagonist (LABA/LAMA) or inhaled corticosteroid/LABA/LAMA combinations were included. Disease stability was defined over a one-year assessment period as meeting all of the following criteria: (1) symptom stability; (2) no moderate or severe exacerbations; and (3) no rapid decline in lung function. The outcomes included acute exacerba

SUBMITTER: Kim SH 

PROVIDER: S-EPMC12778000 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature