Identification of diagnostic biomarkers for ischemic stroke and drug targets of Buyang Huanwu decoction: A bioinformatics and network pharmacology study.

ABSTRACT: Buyang Huanwu decoction (BHD) is extensively employed in the management of ischemic stroke (IS), yet its drug targets and mechanisms of action in IS remain obscure. Thus, in this investigation, network pharmacology and computational biology techniques were employed to investigate the drug targets of BHD in the management of IS. This study aims to identify diagnostic biomarkers for IS and to elucidate the potential drug target network of BHD using integrated bioinformatics and network pharmacology approaches. mRNA expression profiles (GSE16561, GSE58294) were retrieved from the Gene Expression Omnibus (GEO). BHD compounds were obtained from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database (oral bioavailability ≥ 30 %, drug-likeness ≥ 0.18). Predicted compound targets (

SUBMITTER: Fu S 

PROVIDER: S-EPMC12778084 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature