Mendelian randomization identifies circulating miRNAs as causal mediators of gastric cancer susceptibility and survival outcomes.

ABSTRACT: Gastric cancer (GC) remains a leading cause of cancer mortality, yet the causal roles of microRNAs (miRNAs) in its pathogenesis are poorly characterized. While observational studies implicate miRNAs in GC progression, confounding biases and tissue-specific limitations hinder causal inference and clinical translation. We conducted a 2-sample Mendelian randomization (MR) analysis using genetic instruments derived from plasma miRNA expression quantitative trait loci (eQTLs). Summary-level data for miRNA-eQTLs were obtained from a study by Huan et al. (involving 5239 individuals and 280 miRNAs), while genetic associations with GC were sourced from 3 independent genome-wide association studies (ebi-a-GCST90018849, ebi-a-GCST90018629, and bbj-a-119) accessed via the IEU OpenGWAS Project. Instrum

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12778131 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature