Does amitriptyline help for irritable bowel syndrome pain management?: An updated systematic review and meta-analysis.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders (FGIDs) worldwide. Amitriptyline is commonly prescribed for managing the symptoms of IBS as a second-line treatment. This study aimed to consolidate the existing evidence on the pain therapeutic efficacy of amitriptyline in adults with IBS.

Methods

Following the PRISMA guidelines, we conducted an updated systematic review and meta-analysis of observational studies and randomized controlled trials, searching 4 databases (PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials) from inception until March 15, 2024.

Results

The study included 15 studies involving 1497 patients with IBS, 12 of which were included in the meta-analysis. The

SUBMITTER: Alhajaji R 

PROVIDER: S-EPMC12778161 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature