Advancing coronary artery disease diagnosis: Profiling of long noncoding RNAs in small extracellular vesicles from peripheral blood mononuclear cells.

ABSTRACT: Long noncoding RNAs (lncRNAs) play pivotal roles in various physiological processes and significantly influence the pathogenesis of cardiovascular diseases. This study aims to explore the potential clinical utility of lncRNAs as serological biomarkers for diagnosing coronary artery disease (CAD). To investigate lncRNA expression profiles, we utilized a lncRNA microarray to analyze small extracellular vesicles (sEVs) isolated from peripheral blood monocytes of 3 CAD patients and 3 age- and sex-matched healthy controls. Differentially expressed lncRNAs in both plasma and monocyte-derived sEVs were validated using quantitative real-time polymerase chain reaction. A diagnostic model for CAD, integrating lncRNA expression data, was developed through Random Forest and nomogram analyses. The anal

SUBMITTER: Liu X 

PROVIDER: S-EPMC12778187 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature