Investigating causal associations between serum metabolites and cataract by Mendelian randomization.

ABSTRACT: Early studies have demonstrated that systemic metabolic changes can significantly contribute to the development and progression of cataract, however, the causal effects of specific human serum metabolites on cataract have not been fully elucidated. The causal effects of 7 serum metabolites, including proline, serine, 3-dehydrocarnitine, N-[3-(2-oxopyrrolidin-1-yl)propyl]acetamide, octanoylcarnitine, decanoylcarnitine, and citrate, on cataract were analyzed using a 2-sample multivariable Mendelian randomization (MR). Using data from multiple genome-wide association study datasets, which fall under the broad category of the studied serum metabolites, we identified instrumental variables following strict criteria. We then analyzed a FinnGen genome-wide association study dataset, which include

SUBMITTER: Yang X 

PROVIDER: S-EPMC12778205 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature