Prospective assessment of serum neurofilament light chain in platinum-induced and taxane-induced peripheral neuropathy.

ABSTRACT:

Introduction

Chemotherapy-induced peripheral neuropathy (CIPN) is a potentially disabling complication of the neurotoxic chemotherapies; however, its occurrence is often unpredictable. We aimed to determine whether serum levels of neurofilament light chain (sNfL) could predict the onset and severity of CIPN, and whether sNfL levels were associated with other clinical factors in people with cancer.

Methods

Adult patients (>18 years) prescribed at least four cycles of oxaliplatin, cisplatin, docetaxel or paclitaxel were clinically assessed and had blood taken for sNfL analysis at baseline and prior to each cycle. Peak sNfL was compared with clinical characteristics and Total Neuropathy Score-Clinical version (TNSc), National Cancer Institute Common Terminology Criteria for Adv

SUBMITTER: Smyth D 

PROVIDER: S-EPMC12778218 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature