Midazolam oral solution for neonatal MRI: study protocol of a randomised controlled trial.

ABSTRACT:

Introduction

Current medications used for neonatal MRI sedation may lead to complications such as decreased oxygen saturation, apnoea and bradycardia. There has been no study investigating the application of midazolam oral solution in neonatal MRI examinations. Therefore, this study aims to observe the safety and efficacy of midazolam oral solution for sedation during neonatal MRI examinations, providing a reference for clinical application.

Methods and analysis

We designed a double-blind randomised controlled trial. A total of 140 neonates who underwent MRI are included. The neonates are randomly assigned into two groups of n=70 each to receive either midazolam oral solution or chloral hydrate oral solution. The primary outcome indicator of the study is the success rate of

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC12778226 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature