Bidirectional causal relationships between antibody-mediated immune responses and autoimmune diseases: Insights from Mendelian randomization analysis.

ABSTRACT: Autoimmune diseases like systemic lupus erythematosus (SLE) and multiple sclerosis (MS) involve intricate interactions between immune responses and genetic factors, and this study aimed to explore the causal and bidirectional relationships between antibody-mediated immune responses and these diseases to deepen understanding of their mechanisms. A bidirectional 2-sample Mendelian randomization (MR) approach was used, with genetic variants as instrumental variables; antibody data were obtained from the UK Biobank, and autoimmune disease data from the FinnGen database. Generalized summary data-based MR and complementary MR methods were applied to ensure robust results, and Bonferroni-adjusted thresholds were used to address multiple testing. The results showed that elevated levels of Epstein-

SUBMITTER: Huang L 

PROVIDER: S-EPMC12778236 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature