Cerebrospinal fluid metabolites and multiple sclerosis: A two-sample Mendelian randomization study.

ABSTRACT: Epidemiological evidence suggests that cerebrospinal fluid (CSF) metabolites are associated with multiple sclerosis (MS). However, the causality remains unclear as a consequence of confounding or reverse causation. As a result, we evaluated the causal relationship between CSF metabolites and MS. A 2-sample Mendelian randomization analysis was performed for 338 CSF metabolites and MS, with causal relationship elucidated based on genome-wide association studies (GWAS) data. Summary statistics for 338 CSF metabolites were retrieved from a GWAS of 689 participants, and summary statistics for MS consisted of GWAS data including 115,803 participants (47,429 patients and 68,374 controls). The inverse-variance weighted method has been applied to perform primary analysis, and extensive sensitivity

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12778237 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature