Primary central nervous system T-cell lymphoma: a single-centre retrospective study and literature review.

ABSTRACT:

Background

Primary central nervous system T-cell lymphoma (PCNSTL) is an exceptionally rare central nervous system lymphoma with limited clinical data. We present a large case review series of PCNSTL to summarise the clinical characteristics of this disease.

Methods

This study integrated 4 new cases of PCNSTL from our centre with 132 previously reported cases identified through a systematic search of PubMed, Cochrane Library and Web of Science databases.

Results

A total of 136 PCNSTL cases were identified, with a median age of 41 years (range 2-89 years), and a male-to-female ratio of 1.8:1. Peripheral T-cell lymphoma-not otherwise specified was the most prevalent pathological subtype. Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALK+ALCL)

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12778325 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature