What is the psychological and cognitive impact of returning Alzheimer disease dementia research results to healthy research participants? a delayed-start randomised clinical trial protocol for the WeSHARE study (Washington University study of having Alzheimer disease <b>r</b>esearch results explained).

ABSTRACT:

Introduction

Returning research results that indicate risk of Alzheimer disease (AD) dementia-a disease for which no meaningful treatments or cure exist-to cognitively normal participants is controversial. AD is thought to begin many years before clinical signs and symptoms begin. During this time, individuals are cognitively normal but have biomarkers that indicate pathophysiological changes in the brain. With this study, we aim to evaluate the impact of returning research results on cognitively normal participants recruited from a longitudinal observational cohort on ageing at the Knight Alzheimer Disease Research Centre (Knight ADRC) at Washington University in St. Louis.

Methods and analysis

Our study uses a 2-year, delayed-start randomised clinical trial design. Partici

SUBMITTER: Hartz SM 

PROVIDER: S-EPMC12778337 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature