Association between Pre-stroke Frailty and Clinical Outcomes: A Systematic Review and Meta-analysis.

ABSTRACT:

Objective

The relationship between pre-stroke frailty and clinical outcomes remains unclear. This systematic review aimed to examine the association of pre-stroke frailty with mortality, length of stay (LOS), and functional outcomes in people with stroke.

Methods

We used several databases, including PubMed, EMBASE, and CENTRAL. We searched for studies investigating the association between pre-stroke frailty and clinical outcomes. The Quality in Prognosis Studies tool was used to assess the risk of bias in the included studies. Meta-analyses were performed using the random effects model. The certainty of evidence was assessed with the Grading of Recommendations, Assessment, Development, and Evaluation.

Results

Fourteen studies (participants: 11583) were included in thi

SUBMITTER: Murai I 

PROVIDER: S-EPMC12778358 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature