Lanthanide complexes with acetophenone-based push-pull antennas as efficient MRI and two-photon microscopy imaging probes.

ABSTRACT: Lanthanide(iii) (Ln³⁺) complexes possess unique magnetic and optical properties that make them ideal candidates for the development of multimodal MRI and optical probes. However, the requirements for developing effective MRI and optical probes are difficult to meet within a single ligand. Here, we propose the use of a DOTA-type ligand equipped with a π-extended acetophenone moiety that (i) serves as a coordinating moiety to form stable Ln³⁺ complexes, (ii) acts as a 2P-excitable push-pull antenna to sensitize Eu³⁺ luminescence, and (iii) displays a carboxylate handle offering high water solubility and enabling conjugation to biomolecules for targeting purposes. We show that the Ln³⁺ complexes obtained are kinetically inert and thermodynamically s

SUBMITTER: Chartier B 

PROVIDER: S-EPMC12778361 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature