Microglia are dispensable for experience-dependent refinement of mouse visual circuitry.

ABSTRACT: To test the hypothesized crucial role of microglia in the developmental refinement of neural circuitry, we depleted microglia from mice of both sexes with PLX5622 and examined the experience-dependent maturation of visual circuitry and function. We assessed retinal function, receptive field tuning of visual cortex neurons, acuity and experience-dependent plasticity. None of these measurements detectibly differed in the absence of microglia, challenging the role of microglia in sculpting neural circuits.

SUBMITTER: Brown TC 

PROVIDER: S-EPMC12778394 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature