Association of Remnant Cholesterol With Self‑Reported Trouble Sleeping and Mediation by Depression.

ABSTRACT:

Purpose

Remnant cholesterol (RC) is an independent risk factor for cardiovascular diseases. The objective of this study is to assess the correlation between RC levels and trouble sleeping among U.S. adults.

Methods

This study analyzed data from 14,617 adults enrolled in the National Health and Nutrition Examination Survey (NHANES), calculating RC by subtracting both high-density and low-density lipoprotein cholesterol (HDL-c and LDL-c) from total cholesterol (TC). Trouble sleeping was identified through self-report history. The relationship between RC and trouble sleeping was explored through logistic regression, restricted cubic spline (RCS), and mediation analysis.

Results

The prevalence of trouble sleeping escalates with increasing RC levels. Adjusting for potentia

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12778401 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature