Anti-Diabetic Effects of Ayanin, a Flavonoid Compound, in STZ/HFD-Induced Diabetic Mice by Upregulating GLUT4 and Suppressing Macrophage-Driven Inflammation in Adipose Tissues.

ABSTRACT: Insulin resistance, marked by reduced GLUT4 expression in metabolic tissues such as adipose tissue and skeletal muscle, is a key contributor to the pathogenesis of Type 2 diabetes. Therapeutic agents that enhance GLUT4 expression in these tissues have demonstrated potential in the treatment of diabetes. Ayanin (AYN) is a flavonoid found in red wine grapes. This study evaluated the anti-diabetic properties of AYN and investigated its mechanisms. In an in vivo study, the oral administration of AYN to diabetic mice resulted in ameliorated hyperglycemia and glucose tolerance and alleviated lipid dysfunction. The investigation into the underlying mechanisms revealed that AYN activated p-AMPKα, which subsequently enhanced GLUT4 and CPT-1α expression in both adipose and muscle tissues, as well as

SUBMITTER: Lv Y 

PROVIDER: S-EPMC12778411 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature