Overall survival, poverty differentials, and mediating pathways among women with breast cancer: South African Breast Cancer and HIV Outcomes cohort.

ABSTRACT:

Background

Breast cancer survival rates in sub-Saharan Africa are low. In a prospective, multi-center cohort study, we estimated 5-year overall survival rates, overall survival determinants, and mediating effects between socioeconomic status on overall survival among South African women diagnosed with invasive BC.

Patients and methods

Patients from 4 public hospitals were enrolled between July 1, 2015 and January 31, 2019. Survival determinants were assessed using Cox proportional hazard models adjusted for age, background mortality, and treatments. Socioeconomic pathway effects on overall survival were determined through generalized structural equation models.

Results

Of 2838 participants, 58% had advanced-stage (III/IV) disease. Five-year crude overall survival was

SUBMITTER: Joffe M 

PROVIDER: S-EPMC12778425 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature