Association of genetic predisposition to dyslipidemia and physical activity with incident dementia.

ABSTRACT:

Introduction

The association between genetic predisposition to dyslipidemia and dementia risk is inconsistent. It remains unknown whether a physically active lifestyle is associated with a lower dementia risk across different levels of this genetic predisposition.

Methods

We analyzed 198,448 White participants (aged ≥ 60 years) with a median 14.8-year follow-up in UK Biobank. We used Cox proportional hazards models to assess associations between dyslipidemia polygenic risk scores (PRSs), physical activity, and incident dementia.

Results

Higher low-density lipoprotein cholesterol PRS and lower high-density lipoprotein cholesterol PRS were associated with increased risk of all-cause dementia, Alzheimer's disease, and vascular dementia (VaD). Being physically active was

SUBMITTER: Liang Y 

PROVIDER: S-EPMC12778432 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature