A Preliminary Study of Anti-TNFα Therapy for Symptomatic Dolichoectatic Vertebrobasilar Aneurysms.

ABSTRACT:

Background

Dolichoectatic vertebrobasilar aneurysms (DVBAs) carry high morbidity, and treatment options are limited. The tumor necrosis factor α signaling cascade is implicated in DVBA growth and rupture, but the role of anti-tumor necrosis factor α therapy in DVBA has not been studied.

Methods

A retrospective, case-control study of DVBA at a single institution was performed. Two patients with DVBA were treated with infliximab (tumor necrosis factor α inhibitor) as part of routine therapy for rheumatoid arthritis. Three additional patients diagnosed with DVBA were studied as a control group. Routine brain magnetic resonance imaging/magnetic resonance angiography were measured by 2 blinded neuroradiologists to assess DVBA growth. Baseline comorbidities and clinical outcomes w

SUBMITTER: Caton MT 

PROVIDER: S-EPMC12778465 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature