Preclinical Direct Endoluminal Assessment of Endothelialization After Flow Diversion With Microangioscopy.

ABSTRACT:

Background

Direct endoluminal imaging, such as with our previously described microangioscope, is an emerging adjunct in endovascular cerebral aneurysm management that enables clinicians to delineate between thrombi and visualize neoepithelialization after stent placement with high resolution. The present study sought to study flow diversion in vivo under direct endoluminal imaging, and to validate our findings with histopathology.

Methods

In a rabbit model, we implanted each left common carotid artery with a shielded flow diverter (FD) (Medtronic Pipeline Vantage) and nonshielded FD (Medtronic Pipeline Flex) in the right common carotid artery. We studied 9 animals in 3 groups: (1) no periprocedural antiplatelet therapy, (2) aspirin 81 mg daily, and (3) aspirin 81 mg and clop

SUBMITTER: Srinivasan VM 

PROVIDER: S-EPMC12778556 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature