Iron Accumulation and Metabolic Alterations in Aneurysmal Subarachnoid Hemorrhage.

ABSTRACT:

Background

Aneurysmal subarachnoid hemorrhage (aSAH) is a severe type of stroke that is associated with poor outcome. A subset of patients with aSAH will develop secondary complications, most notably delayed cerebral ischemia (DCI), which potentiates neurological injury. In this study, we investigate the relationship between cerebrospinal fluid (CSF) iron accumulation, brain metabolism, and neuronal injury in patients with aSAH with or without DCI.

Methods

We collected longitudinal CSF samples of patients immediately after hospitalization and 5 to 8 days after onset of ictus. CSF was analyzed with electron paramagnetic resonance spectroscopy and metabolomics to determine the presence of redox-active iron species and metabolic alterations associated with aSAH and DCI. Neurona

SUBMITTER: Pacheco G 

PROVIDER: S-EPMC12778566 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature