Association of White Matter Disease With Functional Recovery and 90-Day Outcome After EVT: Beyond Chronological Age.

ABSTRACT:

Background

Patients with white matter disease (WMD) - a key marker of cerebral small vessel disease - may have less brain reserve to cope with ischemic injury. The relationship of WMD to functional recovery after endovascular thrombectomy is uncertain. We aim to explore the association between WMD and functional outcome, assessed at multiple time-points postendovascular thrombectomy.

Methods

In this post hoc analysis, we analyzed noncontrast computed tomography-imaging from the ESCAPE-NA1 (Safety and Efficacy of Nerinetide [NA-1] in Subjects Undergoing Endovascular Thrombectomy for Stroke) trial and assessed WMD by using the total Fazekas-score (score range: 0-6). The primary outcome was repeated measurements of the modified Rankin scale (mRS) scores (i.e., day-5/discharge,

SUBMITTER: Benali F 

PROVIDER: S-EPMC12778645 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature