Global gene expression profiling in whole-blood samples from individuals exposed to metal fumes.

ABSTRACT: Accumulating evidence demonstrates that particulate air pollutants can cause both pulmonary and airway inflammation. However, few data show that particulates can induce systemic inflammatory responses. We conducted an exploratory study using microarray techniques to analyze whole-blood total RNA in boilermakers before and after occupational exposure to metal fumes. A self-controlled study design was used to overcome the problems of larger between-individual variation interferences with observations of relatively smaller changes caused by environmental exposure. Moreover, we incorporated the dichotomous data of absolute gene expression status in the microarray analyses. Compared with nonexposed controls, we observed that genes with altered expression in response to particulate exposure were

SUBMITTER: Wang Z 

PROVIDER: S-EPMC1277870 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature