Preclinical Large Vessel Occlusion Stroke Model: Capybaras (<i>Hydrochoerus</i> <i>hydrochoeris</i>).

ABSTRACT:

Background

Existing preclinical large vessel occlusion stroke models have multiple limitations. We evaluated the capybara (Hydrochoerus hydrochoeris), the largest living rodent possessing sizable cerebral cortex with gyral complexity and large caliber vessels that share many intracranial vascular attributes as seen in humans, as a potential large vessel occlusion stroke model.

Methods

Conventional angiography was performed in an 18-month-old capybara. We (1) investigated the angiographic architecture, (2) evaluated the feasibility of microcatheter navigation and stent-retriever deployment/retraction in the intracranial vessels and the associated arterial histological changes, (3) evaluated the leptomeningeal collateral pattern following transient large vessel occlusio

SUBMITTER: Haussen DC 

PROVIDER: S-EPMC12778801 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature