Decreased 24-hour Parasympathetic Activity following Intracerebral Hemorrhage: A Key Factor Correlated with Adverse Perihematomal Edema and Poor Functional Outcomes.

ABSTRACT:

Aims

This study aimed to investigate the association between autonomic activity, assessed by 24-hour heart rate variability (HRV), and the development of perihematomal edema (PHE) as well as 3-month functional outcomes following intracerebral hemorrhage (ICH).

Methods

We retrospectively included patients with ICH who underwent 24-hour electrocardiographic (ECG) monitoring within 14 days of onset from a prospective cohort. HRV parameters were calculated from ECG data. A poor functional outcome at 3 months was defined as a modified Rankin Scale (mRS) score ≥ 3. PHE volume was measured on 7-day computed tomography scans using 3D Slicer software, and adverse PHE was defined as relative PHE (edema volume/hematoma volume) ≥ 2. Univariate and multivariate logistic regression analys

SUBMITTER: Kang K 

PROVIDER: S-EPMC12778931 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature