Insulin resistance indicators in aortic disease: A large cohort study.

ABSTRACT:

Background

The triglyceride-glucose index (TyG), a novel marker of insulin resistance, is recognised as a risk factor for multiple cardiovascular diseases. The link between its risk and aortic dissection and aortic aneurysm (AD/AA) is not well-defined. This research seeks to explore the relationship.

Methods

This study analysed 386 063 participants from the UK Biobank, a large prospective cohort, all initially free of AD/AA. The main focus was on the occurrence rate of AD/AA. Multivariate Cox regression models were used to analyse the association between the TyG index, its related parameters, and the risk of AD/AA. Association was further validated using a real-world clinical cohort from Central China Fuwai Hospital. A two-sample Mendelian randomisation (MR) analysis utilisi

SUBMITTER: Shao Z 

PROVIDER: S-EPMC12778938 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature