NF1-Specific Growth Charts for Head Circumference Over the First 3 Years of Life.

ABSTRACT:

Background and objectives

Macrocephaly is among the most common findings in neurofibromatosis type 1 (NF1) and may be associated with other clinical manifestations of the genetic syndrome. NF1-specific growth charts that account for expected macrocephaly may increase sensitivity for detecting atypical growth. We aimed to produce NF1-specific growth charts of head circumference for the age range of 0-3 years and to assess their potential clinical impact.

Methods

Using electronic health records from the Children's Hospital of Philadelphia, we collected head circumference measurements from children with NF1 and a community control cohort seen at scheduled well-child visits. We compared head circumference normalized using Centers for Disease Control (CDC) growth charts between t

SUBMITTER: Mandal AS 

PROVIDER: S-EPMC12778977 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature