Clinical characteristics of Graves' disease following COVID-19 infection or vaccination: a multicenter case-control study.

ABSTRACT:

Background/aim

To describe Graves' Disease (GD) associated with COVID-19 infection (COVID) or its vaccines (VAC) and to compare the clinical presentations, laboratory parameters, and short-term clinical course of the disease among different etiology groups (COVID, VAC, and GD control).

Materials and methods

Included in this multicenter matched case-control, retrospective cohort study were 239 patients with newly diagnosed (n = 196) or recurrent GD (n = 43) associated with COVID (n = 79) or VAC (n = 160). Each case was matched (1:1) with a control who had been diagnosed with GD prior to COVID.

Results

The median age of the entire group was 42 years (female:male = 137:102). Both the COVID (4.6-fold) and VAC (4.1-fold) groups demonstrated higher TSH receptor antibody (TR

SUBMITTER: Gokcay Canpolat A 

PROVIDER: S-EPMC12779019 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature