A pilot study on early microgliogenesis following unilateral vestibular neurectomy: A key player in vestibular compensation?

ABSTRACT: Following unilateral vestibular damage, several behavioral deficits arise, referred to as vestibular syndrome. At the central level the vestibular syndrome is associated with an imbalance in neuronal activity between the two vestibular nuclei (VN). Its recovery is correlated with a rebalancing of the electrophysiological activity between both VN, known as vestibular compensation. Key plasticity mechanisms within the VN involved in this mechanism include, among others, neurogliogenesis, modulation of neuronal excitability and increased histamine release. In this study, we aimed to characterize the acute glial cell differentiation lineage in response to unilateral vestibular neurectomy (UVN) in the deafferented VN. We further assessed whether this response is influenced by the histaminergic

SUBMITTER: Trico J 

PROVIDER: S-EPMC12779071 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature