Comparative Evaluation of the Antibacterial Efficacy of Metronidazole, Chlorhexidine, and Normal Saline as Laser- and Sonic-Activated Intracanal Irrigants Against <i>Enterococcus faecalis</i>: In Vitro Study Protocol.

ABSTRACT:

Background

The persistence of Enterococcus faecalis is a significant challenge in endodontic therapy, due to its ability to form biofilms and penetrate the dentinal tubules, frequently leading to treatment failures. Therefore, despite the proven antimicrobial activity of metronidazole (MTR) and chlorhexidine (CHX), the resilience of E. faecalis necessitates integrating activation techniques. Laser and sonic activation methods show promise in enhancing the antibacterial performance of irrigants. However, studies on the activation-enhanced efficacy of MTR, CHX, and saline remain limited.

Objective

This study aimed to compare the antibacterial efficacy of MTR, CHX, and normal saline as intracanal irrigants when activated by laser and sonic techniques against E. faecalis in extr

SUBMITTER: Deshmukh S 

PROVIDER: S-EPMC12779102 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature