Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination.

ABSTRACT: The Flaviviridae are a family of viruses that include the important arthropod-borne human pathogens dengue virus, West Nile virus, Zika virus, Japanese encephalitis virus, and yellow fever virus. Flavivirus nonstructural protein 1 (NS1) is essential for virus replication but is also secreted from virus-infected cells. Extracellular NS1 acts as a virulence factor during flavivirus infection in multiple ways, including triggering endothelial dysfunction and vascular leak via interaction with endothelial cells. While the role of NS1 in inducing vascular leak and exacerbating pathogenesis is well appreciated, if and how NS1-triggered endothelial dysfunction promotes virus infection remains obscure. Flaviviruses have a common need to disseminate from circulation into specific tissues where viru

SUBMITTER: Puerta-Guardo H 

PROVIDER: S-EPMC12779140 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature