A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum.

ABSTRACT:

Background

Plasmodium falciparum merozoite surface protein 3 is a malaria vaccine candidate that was identified, characterised, and developed based on a unique immuno-clinical approach. The vaccine construct was derived from regions fully conserved among various strains and containing B cell epitopes targeted by human antibodies (from malaria-immune adults) that are able to mediate a monocyte-dependent parasite killing effect. The corresponding long synthetic peptide was administered to 36 volunteers, with either alum or Montanide ISA720 as adjuvant.

Methods and findings

Both formulations induced cellular and humoral immune responses. With alum, the responses lasted up to 12 mo. The vaccine-induced antibodies were predominantly of cytophilic classes, i.e., able to cooperate

SUBMITTER: Druilhe P 

PROVIDER: S-EPMC1277929 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature