Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro.

ABSTRACT:

Objective

Autoimmune encephalitis (AE) is characterized by inflammatory processes in the central nervous system and frequently presents with seizures. Even though an ictogenic potential has been shown for some antibodies against neuronal surface antigens (NSAbs), AE pathophysiology is complex, and NSAbs-independent mechanisms are likely to contribute to seizures. We investigated whether the secretome released by peripheral blood mononuclear cells (PBMCs) from AE patients contributes to seizure generation independently of NSAbs.

Methods

PBMCs were isolated from 19 patients with AE (including both those with and those without detectable NSAbs) and 13 healthy volunteers. After 6 h in culture, the PBMC supernatant (secretome) was infused into a heterologous in vitro whole guinea

SUBMITTER: Prevosti S 

PROVIDER: S-EPMC12779307 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature