Climate change and hyponatremia-related hospital admissions in people with focal epilepsy exposed to carbamazepine or its derivatives.

ABSTRACT:

Objective

To estimate the proportion of individuals with focal epilepsy treated with at least one among carbamazepine (CBZ), oxcarbazepine (OXC), or eslicarbazepine (ESL), who were hospitalized due to hyponatremia-related symptoms in 2024, and to test the hypothesis that there is an association with climatic variables.

Methods

We undertook a prospective study in which people with focal epilepsy treated with at least one of the target drugs and at least one attendance in 2024 formed the study cohort. Individuals who were admitted or seen as outpatients for hyponatremia in 2024 were considered cases and the rest considered controls. Climate analysis was performed in Lamezia Terme, Calabria, Italy.

Results

Seventeen of the entire cohort of 105 (16.2%) had hyponatremia-re

SUBMITTER: Fortunato F 

PROVIDER: S-EPMC12779323 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature