Hippocampal abnormality and response to vagus nerve stimulation in epilepsy.

ABSTRACT: Vagus nerve stimulation (VNS) reduces seizure frequency and severity in some, but not all, individuals with epilepsy. The hippocampus has been implicated in VNS response, but is yet to be studied structurally using T1-weighted (T1w) magnetic resonance imaging (MRI). In this study we hypothesized greater hippocampal abnormality in VNS non-responders. Using hippocampal morphometrics, we extracted the volumes of four hippocampal regions from T1w MRI across three groups; VNS responders ( n=42 ), non-responders ( n=50 ), and healthy controls ( n=100 ). We first calculated the multivariate Mahalanobis distance using z-scores from all four hippocampal regions to measure abnormality relative to controls. We then compared traditional univariate measures to the Mahalanobis distance. Response to VNS

SUBMITTER: Clifford HJ 

PROVIDER: S-EPMC12779329 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature