Prognostic impact of nephrectomy and a prediction model for estimating the survival benefit of nephrectomy for patients with clear cell renal cell carcinoma (ccRCC).

ABSTRACT:

Background

The benefit of nephrectomy for all patients with clear cell renal cell carcinoma (ccRCC) remains controversial. This study assessed the impact of nephrectomy on patient prognosis and developed a prognostic model for nephrectomy-treated patients.

Methods

Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) and The Cancer Genome Atlas databases. Propensity score matching (PSM) was implemented, followed by univariate and multivariate survival analyses to compare overall survival (OS) between ccRCC patients treated with and without nephrectomy. Subsequently, we developed and internally validated a nomogram for predicting OS in nephrectomy-treated patients using multivariate Cox regression modeling.

Results

OS was significantly better

SUBMITTER: Li H 

PROVIDER: S-EPMC12779432 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature