Vascular aging-driven erectile dysfunction: pathophysiological mechanisms and emerging therapies-a narrative review.

ABSTRACT:

Background and objective

Age-related erectile dysfunction (ED) is a significant health concern linked to vascular aging, characterized by endothelial dysfunction and vascular smooth muscle alterations. This study aimed to explores the pathophysiological mechanisms of age-related ED in elderly men, providing new directions for diagnosis and the development of novel targeted therapies.

Methods

This review focused on literature from 2000 to 2025 concerning vascular aging and ED. We searched PubMed, Web of Science, and Embase using keywords like "erectile dysfunction", "aging", "vascular endothelium", and "vascular smooth muscle". The selection process prioritized high-quality clinical and innovative preclinical studies in humans or animal models that explored pathophysiology or

SUBMITTER: Zhong K 

PROVIDER: S-EPMC12779443 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature