Challenge Specific Modulation of Responses to Adjuvant-Induced Innate Immune Memory.

ABSTRACT: Understanding the innate immune memory induced by adjuvants provides an opportunity to improve vaccine efficacy by inducing nonspecific secondary responses alongside the intended adaptive defence against the target antigen. To understand the consequences of adjuvant-induced immune training, we treated mice with commercially available Sigma Adjuvant System (SAS) and performed functional assays of bone marrow-derived innate immune cells, assessed its functional consequences in vivo, determined the resulting haematopoietic stem and progenitor cell (HSPC) phenotypes, and extensively analyzed the HSPC transcriptome. SAS induced temporal shifts in HSPC frequencies, alterations in the circulating blood profile, and lowered proinflammatory output by macrophages. SAS-induced training caused dispara

SUBMITTER: Pasco ST 

PROVIDER: S-EPMC12779450 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature