Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease.

ABSTRACT: Experimental evidence suggests that activated microglia induce astrocyte reactivity in neurodegenerative disorders, such as Alzheimer's disease (AD). In this study, we investigated the association between microglial activation and amyloid-β (Aβ) with reactive astrogliosis in individuals across the AD spectrum. We examined 101 individuals using positron emission tomography radiotracers to assess Aβ deposition ([¹⁸F]AZD4694), tau aggregation ([¹⁸F]MK-6240) and microglial activation ([¹¹C]PBR28), along with plasma biomarkers for astrocyte reactivity (GFAP) and tau phosphorylation (p-tau217). We further evaluated 251 individuals with cerebrospinal fluid levels of the microglial marker sTREM2. We found that Aβ pathology was associated with astrocyte reactivity a

SUBMITTER: Ferrari-Souza JP 

PROVIDER: S-EPMC12779546 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature