Targeting FSP1 triggers ferroptosis in lung cancer.

ABSTRACT: Emerging evidence indicates that cancer cells are susceptible to ferroptosis, a form of cell death that is triggered by uncontrolled lipid peroxidation^1-3. Despite broad enthusiasm about harnessing ferroptosis as a novel anti-cancer strategy, whether ferroptosis is a barrier to tumorigenesis and can be leveraged therapeutically remains unknown^4,5. Here, using genetically engineered mouse models of lung adenocarcinoma, we performed tumour-specific loss-of-function studies of two key ferroptosis suppressors, GPX4^6,7 and ferroptosis suppressor protein 1 (FSP1)^8,9, and observed increased lipid peroxidation and robust suppression of tumorigenesis, suggesting that lung tumours are highly sensitive to ferroptosis. Furthermore, across multiple pre-clinic

SUBMITTER: Wu K 

PROVIDER: S-EPMC12779550 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature