Liver injury in a preclinical model of short bowel syndrome is associated with impaired autophagy.

ABSTRACT: Critical for cellular maintenance and repair, autophagy recycles damaged or redundant cellular components. Dysregulated autophagy is associated with progressive cellular injury in various liver pathologies. However, the role of autophagy in intestinal failure-associated liver disease has not previously been investigated. Using a preclinical murine model of short bowel syndrome, we explored the role of autophagy impairment at early and late time points. Regardless of sex, small bowel resected (SBR) mice demonstrated significant liver injury compared to sham controls, exhibiting elevated serum transaminases, altered liver histology, and increased mRNA expression of endoplasmic reticulum stress marker (Ddit3) and oxidative stress marker (Nqo1). Autophagy impairment was supported by increased

SUBMITTER: Alligood DM 

PROVIDER: S-EPMC12779645 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature