The differential effect of chronological age and brain age on cognitive fatigue: new metrics, new insights.

ABSTRACT: Fatigue is prevalent in the general population, but it is unclear whether aging is associated with increased fatigue. Here, we investigate the relationship between cognitive fatigue (CF, fatigue resulting from mental work) and two types of aging-chronological age and brain age-in 85 participants ranging in age from 20 to 84 years. Whereas chronological age is simply participants' absolute age, brain age is derived from a comparison of participants' brain morphology relative to a normative model. CF was induced using a working memory paradigm that participants repeatedly performed, reporting their instantaneous level of CF at baseline and after each successive block of the task. Chronological age was associated with a decrease in the CF reported at baseline (the intercept of a regression li

SUBMITTER: Wylie GR 

PROVIDER: S-EPMC12779680 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature