Psychological stress and functional ovarian suppression in women with PCOM: an observational study of FHA-like neuroendocrine phenotypes.

ABSTRACT:

Propose

To examine how chronic psychological stress alters gonadotropin dynamics and disrupts ovarian endocrine function in women with polycystic ovarian morphology (PCOM), and to discuss the modulatory role of leptin in this process.

Methods

In this cross-sectional study of 134 women, participants were classified into four groups: three subgroups of women with oligomenorrhea-PCOM with stress, PCOM without stress, and NON-PCOM/NON-STRESS-and a comparison group of eumenorrheic controls. Psychological stress was assessed with validated psychometric instruments (STAI, HADS, PSS-10), and a composite Stress Index was derived. PCOM was defined according to the 2023 International Evidence-based Guideline for PCOS. Stress status was classified using established cut-offs for each ins

SUBMITTER: Silva V 

PROVIDER: S-EPMC12779685 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature