DAZAP1 promotes cancer progression and chemotherapy resistance by stabilizing PIN1 protein in gastric cancer.

ABSTRACT: Gastric cancer (GC) continues to be a fatal disease globally, largely due to the lack of dependable molecular indicators enabling early diagnosis and therapeutic intervention. Single-cell transcriptomic analysis revealed significant enrichment of DAZAP1 in proliferating and malignant gastric epithelial cells. Using a combined analysis of single-cell and bulk RNA-seq datasets, we further recognized DAZAP1 as a putative oncogene correlated with poor clinical outcomes in GC. Functional experiments demonstrated that DAZAP1 promotes tumor proliferation, cell cycle progression, and chemotherapy resistance in vitro and in vivo. Mechanistically, DAZAP1 bound and stabilized USP34 mRNA, leading to increased USP34 protein expression, which in turn mediated the deubiquitination and stabilization of th

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12779690 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature