Dual-functional Mo₂N nanomaterials for photothermal therapy: enhancing MRSA-infected wound healing and selective thyroid cancer ablation.

ABSTRACT: Thyroid cancer treatment and bacterial infection management have long been challenging due to the limited effectiveness and side effects of conventional therapies. Here, we introduce molybdenum nitride (Mo₂N) nanomaterials as an innovative platform for dual-functional photothermal therapy, combining anti-tumor and antibacterial treatments. Mo₂N nanoparticles with an average diameter of ~ 2.45 nm were synthesized and systematically characterized. Upon near-infrared (NIR) laser exposure, Mo₂N demonstrated efficient photothermal conversion (efficiency ≈ 31.8%), leading to significant temperature elevation. In vitro studies confirmed a selective cytotoxic effect, with Mo₂N-mediated PTT inducing significant death in thyroid cancer cells while having a minimal impact on normal endothelial cells.

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12779745 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature